The variety and complexity of biotechnological applications are continually rising, with ever increasing ranges of manufacturing hosts, cultivation situations and measurement duties. Consequently, many analytical and cultivation programs for biotechnology and bioprocess engineering, similar to microfluidic units or bioreactors, are tailored to exactly fulfill the necessities of particular measurements or cultivation duties. Additive manufacturing (AM) technologies supply the likelihood of fabricating tailored 3D laboratory tools instantly from CAD designs with beforehand inaccessible ranges of freedom in phrases of structural complexity.
This assessment discusses the historic background of these technologies, their most promising present implementations and the related workflows, fabrication processes and materials specs, along with some of the key challenges related to utilizing AM in biotechnology/bioprocess engineering. To illustrate the good potential of AM, chosen examples in microfluidic units, 3D-bioprinting/biofabrication and bioprocess engineering are highlighted.
Cuban advances in biotech have made headlines, notably for the reason that US-Cuba rapprochement and signing of the historic memorandum of understanding between the US Department of Health and Human Services and Cuba’s Ministry of Public Health in June. Some 34 Cuban establishments with 22,000 workers are the spine of a biotech trade that dates to the early 1980s, acquiring novel merchandise which have sparked curiosity amongst potential international companions. While a quantity of these Cuban merchandise are registered in numerous nations, their testing in the USA stays ensnared in the pink tape of embargo legal guidelines that are inclined to make buyers skittish and thus delay, if not curtail, joint analysis and scientific trial applications to the FDA.
Safety Profile of Anticancer and Immune-Modulating Biotech Drugs Used in a Real World Setting in Campania Region (Italy): BIO-Cam Observational Study.
To examine the prevalence of hostile occasions (AEs) in naïve sufferers receiving biotech medication. Design: A potential observational examine. Setting: Onco-hematology, Hepato-gastroenterology, Rheumatology, Dermatology, and Neurology Units in Campania Region (Italy). Participants: 775 sufferers (53.81% feminine) with imply age 56.0 (SD 15.2). The imply follow-up/affected person was 3.48 (95% confidence interval 3.13-3.84). Main consequence measures: We collected all AEs related to biotech medication, together with severe infections and malignancies.
Serious AEs have been outlined in keeping with the International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use, scientific security knowledge administration: definitions and requirements for expedited reporting E2A guideline. Results: The majority of the examine inhabitants was enrolled in Onco-hematology and Rheumatology Units and the commonest analysis have been hematological malignancies, adopted by rheumatoid arthritis, colorectal most cancers, breast most cancers, and psoriatic arthritis.
The mostly prescribed biotech medication have been rituximab, bevacizumab, infliximab, trastuzumab, adalimumab, and cetuximab. Out of 775 sufferers, 320 skilled a minimum of one AE. Most of sufferers skilled AEs to cetuximab remedy, rituximab and trastuzumab. Comparing feminine and male inhabitants, our findings highlighted a statistically important distinction in phrases of AEs for adalimumab (35.90% vs. 7.41%, p < 0.001) and etanercept (27.59% vs. 10.00%, p = 0.023). Considering all biotech medication, we noticed a peak for all AEs prevalence at follow-up 91-180 days class. Bevacizumab, brentuximab, rituximab, trastuzumab and cetuximab have been extra generally related to severe hostile occasions; most of these have been probably associated to biotech medication, in keeping with causality evaluation.
Three circumstances of severe infections occurred. Conclusions: The outcomes of our examine demonstrated that almost all of AEs weren’t severe and anticipated. Few circumstances of severe infections occurred, whereas no case of malignancy did. Overall, the protection profile of biotech medication used in our inhabitants was much like these noticed in pivotal trials. Notwithstanding the optimistic outcomes of our examine, some security issues nonetheless stay unresolved. In order to gather extra effectiveness and security knowledge on biotech medication, the gathering and evaluation of actual world knowledge needs to be endorsed in addition to the administration of post-authorization research.

What Will Be the Benefits of Biotech Wheat for European Agriculture?
In European nations, wheat occupies the biggest crop space with excessive yielding manufacturing. France, a significant producer and exporter in Europe, ranks the fifth producer worldwide. Biotic stresses are European farmers’ main challenges (fungal and viral ailments, and insect pests) adopted by abiotic ones similar to drought and grain protein composition. During the final 40 years, 1136 scientific articles on biotech wheat have been printed by USA adopted by China, Australia, Canada, and European Union with the UK. European analysis focuses on pests and ailments resistances utilizing broadly marker-assisted choice (MAS). Transgenesis is used in fundamental analysis to develop resistance towards some fungi (Fusarium head blight) whereas RNA interference (RNAi) silencing is used towards some fungi and virus.
Luciferase Reporter Gene Assay Kit |
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Z5030003 |
Biochain |
1,000 assays |
EUR 1118 |
Dual Luciferase Reporter Gene Assay Kit |
|
KTA8010-1000T |
Abbkine |
1000 T |
EUR 819 |
Dual Luciferase Reporter Gene Assay Kit |
|
KTA8010-100T |
Abbkine |
100 T |
EUR 149 |
Dual Luciferase Reporter Gene Assay Kit |
|
KTA8010-each |
Abbkine |
each |
Ask for price |
Single Firefly Luciferase Reporter Gene Assay Kit |
|
K2236-100 |
ApexBio |
100T |
EUR 68 |
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Description: Transcriptional Regulation|Reporter Gene |
Single Firefly Luciferase Reporter Gene Assay Kit |
|
K2236-1000 |
ApexBio |
1000T |
EUR 336 |
|
Description: Transcriptional Regulation|Reporter Gene |
Enhanced Firefly Luciferase Reporter Gene Assay Kit |
|
RG009M |
Beyotime Biotech Inc |
1000 Tests |
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Enhanced Firefly Luciferase Reporter Gene Assay Kit |
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RG009S |
Beyotime Biotech Inc |
100 Tests |
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Renilla-LumiTM Luciferase Reporter Gene Assay Kit |
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RG062M |
Beyotime Biotech Inc |
1000 Tests |
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Renilla-LumiTM Luciferase Reporter Gene Assay Kit |
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RG062S |
Beyotime Biotech Inc |
100 Tests |
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Enhanced Firefly Luciferase Reporter Gene Assay Kit II |
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RG010M |
Beyotime Biotech Inc |
1000 Tests |
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Enhanced Firefly Luciferase Reporter Gene Assay Kit II |
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RG010S |
Beyotime Biotech Inc |
100 Tests |
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Bio-LumiTM Firefly Luciferase Reporter Gene Assay Kit |
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RG042M |
Beyotime Biotech Inc |
1000 Tests |
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Bio-LumiTM Firefly Luciferase Reporter Gene Assay Kit |
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RG042S |
Beyotime Biotech Inc |
100 Tests |
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One-LumiTM Firefly Luciferase Reporter Gene Assay Kit |
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RG055M |
Beyotime Biotech Inc |
1000 Tests |
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One-LumiTM Firefly Luciferase Reporter Gene Assay Kit |
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RG055S |
Beyotime Biotech Inc |
100 Tests |
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Renilla-LumiTM Plus Luciferase Reporter Gene Assay Kit |
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RG066M |
Beyotime Biotech Inc |
1000 Tests |
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Renilla-LumiTM Plus Luciferase Reporter Gene Assay Kit |
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RG066S |
Beyotime Biotech Inc |
100 Tests |
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Bright-LumiTM Firefly Luciferase Reporter Gene Assay Kit |
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RG051M |
Beyotime Biotech Inc |
1000 Tests |
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Bright-LumiTM Firefly Luciferase Reporter Gene Assay Kit |
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RG051S |
Beyotime Biotech Inc |
100 Tests |
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Steady-LumiTM Firefly Luciferase Reporter Gene Assay Kit |
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RG058M |
Beyotime Biotech Inc |
1000 Tests |
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Steady-LumiTM Firefly Luciferase Reporter Gene Assay Kit |
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RG058S |
Beyotime Biotech Inc |
100 Tests |
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Gaussia-LumiTM Gaussia Luciferase Reporter Gene Assay Kit |
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RG072M |
Beyotime Biotech Inc |
1000 Tests |
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Gaussia-LumiTM Gaussia Luciferase Reporter Gene Assay Kit |
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RG072S |
Beyotime Biotech Inc |
100 Tests |
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Dual-LumiTM II Luciferase Reporter Gene Assay Kit, Dual-LumiTM II Luciferase Assay Kit |
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RG089M |
Beyotime Biotech Inc |
1000 Tests |
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Dual-LumiTM II Luciferase Reporter Gene Assay Kit, Dual-LumiTM II Luciferase Assay Kit |
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RG089S |
Beyotime Biotech Inc |
100 Tests |
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Amplite® Luciferase Reporter Gene Assay Kit *Bright Glow* |
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12518-1plate |
AAT Bioquest |
1 plate |
EUR 166 |
|
|
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Description: Common reporter genes include beta-galactosidase, beta-glucuronidase and luciferase. |
Amplite® Luciferase Reporter Gene Assay Kit *Bright Glow* |
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12519-10plates |
AAT Bioquest |
10 plates |
EUR 446 |
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|
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Description: Common reporter genes include beta-galactosidase, beta-glucuronidase and luciferase. |
Amplite® Luciferase Reporter Gene Assay Kit *Bright Glow* |
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12520-100plates |
AAT Bioquest |
100 plates |
EUR 3321 |
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|
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Description: Common reporter genes include beta-galactosidase, beta-glucuronidase and luciferase. |
Bio-LumiTM II Firefly Luciferase Reporter Gene Assay Kit |
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RG043M |
Beyotime Biotech Inc |
1000 Tests |
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Bio-LumiTM II Firefly Luciferase Reporter Gene Assay Kit |
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RG043S |
Beyotime Biotech Inc |
100 Tests |
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Bio-LumiTM One Firefly Luciferase Reporter Gene Assay Kit |
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RG044M |
Beyotime Biotech Inc |
1000 Tests |
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Bio-LumiTM One Firefly Luciferase Reporter Gene Assay Kit |
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RG044S |
Beyotime Biotech Inc |
100 Tests |
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Bio-LumiTM Steady Firefly Luciferase Reporter Gene Assay Kit |
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RG046M |
Beyotime Biotech Inc |
1000 Tests |
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Bio-LumiTM Steady Firefly Luciferase Reporter Gene Assay Kit |
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RG046S |
Beyotime Biotech Inc |
100 Tests |
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Bio-LumiTM One II Firefly Luciferase Reporter Gene Assay Kit |
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RG045M |
Beyotime Biotech Inc |
1000 Tests |
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Bio-LumiTM One II Firefly Luciferase Reporter Gene Assay Kit |
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RG045S |
Beyotime Biotech Inc |
100 Tests |
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Dual Luciferase Reporter Gene Assay Cell Lysis Buffer |
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RG132M |
Beyotime Biotech Inc |
100 mL |
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Dual Luciferase Reporter Gene Assay Cell Lysis Buffer |
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RG132S |
Beyotime Biotech Inc |
10 mL |
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Bac-LumiTM Bacterial Firefly Luciferase Reporter Gene Assay Kit |
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RG039M |
Beyotime Biotech Inc |
1000 Tests |
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Bac-LumiTM Bacterial Firefly Luciferase Reporter Gene Assay Kit |
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RG039S |
Beyotime Biotech Inc |
100 Tests |
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Amplite® Luciferase Reporter Gene Assay Kit *Maximized Luminescence* |
|
12519 |
AAT Bioquest |
10 plates |
EUR 455 |
|
Description: Common reporter genes include beta-galactosidase, beta-glucuronidase and luciferase. |
Bio-LumiTM Steady II Firefly Luciferase Reporter Gene Assay Kit |
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RG047M |
Beyotime Biotech Inc |
1000 Tests |
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Bio-LumiTM Steady II Firefly Luciferase Reporter Gene Assay Kit |
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RG047S |
Beyotime Biotech Inc |
100 Tests |
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Firefly Luciferase Reporter Gene Assay Cell Lysis Buffer |
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RG126M |
Beyotime Biotech Inc |
100 mL |
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Firefly Luciferase Reporter Gene Assay Cell Lysis Buffer |
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RG126S |
Beyotime Biotech Inc |
10 mL |
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Renilla Luciferase Reporter Gene Assay Cell Lysis Buffer |
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RG129M |
Beyotime Biotech Inc |
100 mL |
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Renilla Luciferase Reporter Gene Assay Cell Lysis Buffer |
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RG129S |
Beyotime Biotech Inc |
10 mL |
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Gaussia Luciferase Reporter Gene Assay Cell Lysis Buffer |
|
RG135M |
Beyotime Biotech Inc |
100 mL |
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Gaussia Luciferase Reporter Gene Assay Cell Lysis Buffer |
|
RG135S |
Beyotime Biotech Inc |
10 mL |
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Amplite® Gaussia Luciferase Reporter Gene Assay Kit *Bright Glow* |
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12530-1plate |
AAT Bioquest |
1 plate |
EUR 222 |
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|
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Description: Common reporter genes include beta-galactosidase, beta-glucuronidase and luciferase. |
Amplite® Gaussia Luciferase Reporter Gene Assay Kit *Bright Glow* |
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12531-10Plates |
AAT Bioquest |
10 Plates |
EUR 846 |
|
|
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Description: Common reporter genes include beta-galactosidase, beta-glucuronidase and luciferase. |
Amplite® Gaussia Luciferase Reporter Gene Assay Kit *Bright Glow* |
|
12532-100plates |
AAT Bioquest |
100 plates |
EUR 4447 |
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Description: Common reporter genes include beta-galactosidase, beta-glucuronidase and luciferase. |
Amplite® Renilla Luciferase Reporter Gene Assay Kit *Bright Glow* |
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12535-1plate |
AAT Bioquest |
1 plate |
EUR 222 |
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Description: Common reporter genes include beta-galactosidase, beta-glucuronidase and luciferase. |
Amplite® Renilla Luciferase Reporter Gene Assay Kit *Bright Glow* |
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12536-10plates |
AAT Bioquest |
10 plates |
EUR 1070 |
|
|
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Description: Common reporter genes include beta-galactosidase, beta-glucuronidase and luciferase. |
Amplite® Renilla Luciferase Reporter Gene Assay Kit *Bright Glow* |
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12537-100plates |
AAT Bioquest |
100 plates |
EUR 4447 |
|
|
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Description: Common reporter genes include beta-galactosidase, beta-glucuronidase and luciferase. |
Luciferase Reporter Assay Kit |
|
GWB-AXR371 |
GenWay Biotech |
200 assays |
Ask for price |
Luciferase Reporter Assay Kit |
|
K2181-200 |
ApexBio |
200 assays |
EUR 204.8 |
|
Description: Tools Kit|Molecular Biology Kit#Kits|Tools Kit#Kits |
Luciferase Reporter Assay Kit |
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K801-200 |
Biovision |
each |
EUR 235.2 |
One-LumiTM II Firefly Luciferase Reporter Gene Assay Kit, One-LumiTM II Firefly Luciferase Assay Kit |
|
RG056M |
Beyotime Biotech Inc |
1000 Tests |
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One-LumiTM II Firefly Luciferase Reporter Gene Assay Kit, One-LumiTM II Firefly Luciferase Assay Kit |
|
RG056S |
Beyotime Biotech Inc |
100 Tests |
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Bright-LumiTM II Firefly Luciferase Reporter Gene Assay Kit, Bright-LumiTM II Firefly Luciferase Assay Kit |
|
RG052M |
Beyotime Biotech Inc |
1000 Tests |
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Bright-LumiTM II Firefly Luciferase Reporter Gene Assay Kit, Bright-LumiTM II Firefly Luciferase Assay Kit |
|
RG052S |
Beyotime Biotech Inc |
100 Tests |
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Steady-LumiTM II Firefly Luciferase Reporter Gene Assay Kit, Steady-LumiTM II Firefly Luciferase Assay Kit |
|
RG059M |
Beyotime Biotech Inc |
1000 Tests |
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Steady-LumiTM II Firefly Luciferase Reporter Gene Assay Kit, Steady-LumiTM II Firefly Luciferase Assay Kit |
|
RG059S |
Beyotime Biotech Inc |
100 Tests |
Ask for price |
Amplite® Renilla Luciferase Reporter Gene Assay Kit *Maximized Luminescence* |
|
12536 |
AAT Bioquest |
10 plates |
EUR 1092 |
|
Description: Common reporter genes include beta-galactosidase, beta-glucuronidase and luciferase. |
Enhanced Firefly Luciferase Reporter Gene Assay Cell Lysis Buffer |
|
RG127M |
Beyotime Biotech Inc |
100 mL |
Ask for price |
Enhanced Firefly Luciferase Reporter Gene Assay Cell Lysis Buffer |
|
RG127S |
Beyotime Biotech Inc |
10 mL |
Ask for price |
Dual Luciferase Reporter Assay Kit |
|
DL101-01 |
Vazyme |
100 rxn |
EUR 90.5 |
Dual Luciferase Reporter Assay Kit |
|
DL101-01-100rxns |
Vazyme |
100 rxns |
EUR 93.71 |
T24 Luciferase Reporter Cell Line |
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ABC-RC123H |
AcceGen |
each |
Ask for price |
|
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4T1 Luciferase Reporter Cell Line |
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ABC-RC286H |
AcceGen |
each |
Ask for price |
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T84 Luciferase Reporter Cell Line |
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ABC-RC724H |
AcceGen |
each |
Ask for price |
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SCC7 Luciferase Reporter Cell Line |
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ABC-RC135H |
AcceGen |
each |
Ask for price |
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MB49 Luciferase Reporter Cell Line |
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ABC-RC648H |
AcceGen |
each |
Ask for price |
|
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C1498 Luciferase Reporter Cell Line |
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ABC-RC160H |
AcceGen |
each |
Ask for price |
|
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TU686 Luciferase Reporter Cell Line |
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ABC-RC735H |
AcceGen |
each |
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PC-9 Luciferase Reporter Cell Line |
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ABC-RC120H |
AcceGen |
each |
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HuH-7 Luciferase Reporter Cell Line |
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ABC-RC183H |
AcceGen |
each |
Ask for price |
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A-673 Luciferase Reporter Cell Line |
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ABC-RC568H |
AcceGen |
each |
Ask for price |
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C666-1 Luciferase Reporter Cell Line |
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ABC-RC054H |
AcceGen |
each |
Ask for price |
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JIMT-1 Luciferase Reporter Cell Line |
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ABC-RC628H |
AcceGen |
each |
Ask for price |
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NALM-6 Luciferase Reporter Cell Line |
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ABC-RC665H |
AcceGen |
each |
Ask for price |
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B16-OVA Luciferase Reporter Cell Line |
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ABC-RC578H |
AcceGen |
each |
Ask for price |
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MOLM-13 Luciferase Reporter Cell Line |
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ABC-RC662H |
AcceGen |
each |
Ask for price |
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NCI-H520 Luciferase Reporter Cell Line |
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ABC-RC113H |
AcceGen |
each |
Ask for price |
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NIH:OVCAR-3 Luciferase Reporter Cell Line |
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ABC-RC203H |
AcceGen |
each |
Ask for price |
|
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HCC-1937 Luciferase Reporter Cell Line |
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ABC-RC305H |
AcceGen |
each |
Ask for price |
|
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NCI-H446 Luciferase Reporter Cell Line |
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ABC-RC674H |
AcceGen |
each |
Ask for price |
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HRE Luciferase Reporter-HeLa Cell Line |
|
RC1018 |
BosterBio |
1 Vial, Each vial contains 2 ~ 3 x 10^6 cells in 1 ml of 90% FBS + 10% DMSO. |
EUR 1864.8 |
|
Description: The HRE Luciferase Reporter cell line is a stably transfected HeLa cell line which expresses Renilla luciferase reporter gene under the transcriptional control of the hypoxia response element (HRE). In response to hypoxia (low oxygen), HREs of target genes are recognized and regulated by the hypoxia-inducible factors (HIFs) which belong to the family of basic helix-loop-helix transcription factors and form heterodimeric complex comprising the alpha subunit (HIF-1 alpha, HIF-2 alpha and HIF-3 alpha) and beta subunit (Arnt1, Arnt2 and Arnt3), among which HIF-1 alpha and HIF-2 alpha are predominant isoforms. Activation of HIFs can also be mediated by chemical hydroxylase inhibitors as hypoxia mimetics including the iron chelator desferrioxamine and cobalt chloride.The HRE induction by cobalt chloride is shown in Figure 1. |
p53 Luciferase Reporter-HeLa Cell Line |
|
RC1026 |
BosterBio |
1 Vial, Each vial contains 2 ~ 3 x 10^6 cells in 1 ml of 90% FBS + 10% DMSO. |
EUR 1864.8 |
Description: The p53 Luciferase Reporter cell line is a stably transfected HeLa cell line which expresses Renilla luciferase reporter gene under the transcriptional control of the p53 response element. p53 is a tumor suppressor that plays a crucial role in apoptosis and anticancer mechanisms. p53 reporter system is designed to monitor the p53-mediated signaling pathways.The p53 induction by doxorubicin is shown in Figure 1. |
MRE Luciferase Reporter HEK293 Cell Line |
|
RC1037 |
BosterBio |
1 Vial, Each vial contains 2 ~ 3 x 10^6 cells in 1 ml of 90% FBS + 10% DMSO. |
EUR 1864.8 |
|
Description: The MRE Luciferase Reporter cell line is a stably transfected HEK 293 cell line which expresses Renilla luciferase reporter gene under the transcriptional control of the metal response element (MRE). MRE is targeted by MRE-binding transcription factor-1 (MTF-1) which is a zinc finger transcription factor and plays a major role in induction of metallothionein gene expression in response to cellular stress caused by heavy metals such as zinc and cadmium. The MRE induction by ZnSO4 is shown in Figure 1. |
NCI-H1975 Luciferase Reporter Cell Line |
|
ABC-RC338H |
AcceGen |
each |
Ask for price |
|
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Nrf2 Luciferase Reporter-MCF7 Cell Line |
|
RC1017 |
BosterBio |
1 Vial, Each vial contains 2 ~ 3 x 10^6 cells in 1 ml of 90% FBS + 10% DMSO. |
EUR 1864.8 |
|
Description: The Nrf2 Luciferase Reporter cell line is a stably transfected MCF7 cell line which expresses Renilla luciferase reporter gene under the transcriptional control of the antioxidant response element (ARE). ARE is known to regulate expression and induction of various detoxifying enzyme genes in response to antioxidants and xenobiotics, and is primarily regulated by the Keap1-Nrf2 pathway in which induction and nuclear translocation of Nrf2 mediated by antioxidants and xenobiotics results in the binding of Nrf2 to ARE leading to the expression of defensive genes. The Nrf2 induction by dimethyl fumarate (DMF) is shown in Figure 1. |
ATF6 Luciferase Reporter-HeLa Cell Line |
|
RC1038 |
BosterBio |
1 Vial, Each vial contains 2 ~ 3 x 10^6 cells in 1 ml of 90% FBS + 10% DMSO. |
EUR 1864.8 |
|
Description: The ATF6 Luciferase Reporter cell line is a stably transfected HeLa cell line which expresses Renilla luciferase reporter gene under the transcriptional control of the activating transcription factor 6 (ATF6)-response element. ATF6 is a member of the basic-leucine zipper transcription factor family, which is located in the endoplasmic reticulum (ER) membranes and plays a central role in transcriptional activation of ER molecules. The ATF6 induction by Tunicamycin is shown in Figure 1. |
U-251 MG Luciferase Reporter Cell Line |
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ABC-RC354H |
AcceGen |
each |
Ask for price |
|
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STAT1 Luciferase Reporter-HeLa Cell Line |
|
RC1012 |
BosterBio |
1 Vial, Each vial contains 2 ~ 3 x 10^6 cells in 1 ml of 90% FBS + 10% DMSO. |
EUR 4536 |
Description: The STAT1 Luciferase Reporter cell line is a stably transfected HeLa cell line which expresses Renilla luciferase reporter gene under the transcriptional control of the interferon (IFN) gamma activation sequence-based STAT1 response element, so that the cell line is designed to measure the transcriptional activity of STAT1. As a transcription factor, Signal Transducer and Activator of Transcription 1 (STAT1) is activated through phosphorylation at tyrosine 701 in response to various cytokines and growth factors such as IFN-alpha, IFN-gamma, IL-6, EGF and PDGF. The phosphorylated STAT1 forms homodimers or heterodimers with STAT3, and the dimers translocate to nucleus in which DNA binding/promoter induction occurs. The STAT1 induction by IFN-gamma is shown in Figure 1. |
SRE Luciferase Reporter-HEK293 Cell Line |
|
RC1032 |
BosterBio |
1 Vial, Each vial contains 2 ~ 3 x 10^6 cells in 1 ml of 90% FBS + 10% DMSO. |
EUR 2772 |
|
Description: The SRE Luciferase Reporter cell line is a stably transfected HEK 293 cell line which expresses Renilla luciferase reporter gene under the transcriptional control of the serum response element (SRE). The SRE reporter cell line is designed to monitor MAPK/ERK activity and can be used for studying GPCR-linked MAPK/ERK signaling pathways as well as screening of agonists, antagonists or signaling inhibitors related with the MAPK/ERK signaling pathways. Functional activity of the cell line has been validated by serum stimulation assay (Figure 1). |
CRE Luciferase Reporter-HEK293 Cell Line |
|
RC1034 |
BosterBio |
1 Vial, Each vial contains 2 ~ 3 x 10^6 cells in 1 ml of 90% FBS + 10% DMSO. |
EUR 2772 |
Description: The CRE Luciferase Reporter cell line is a stably transfected HEK 293 cell line which expresses Renilla luciferase reporter gene under the transcriptional control of the cAMP response element (CRE). The CRE cell line is designed to monitor the cAMP/PKA signaling pathways and can be used for studying GPCR-linked cAMP/PKA signaling pathways as well as screening of agonists, antagonists or signaling inhibitors related with the cAMP/PKA signaling pathways. Functional activity of the cell line has been validated by serum stimulation assay (Figure 1). |
SBE Luciferase Reporter-HEK293 Cell Line |
|
RC1036 |
BosterBio |
1 Vial, Each vial contains 2 ~ 3 x 10^6 cells in 1 ml of 90% FBS + 10% DMSO. |
EUR 1864.8 |
|
Description: The SBE Luciferase Reporter cell line is a stably transfected HEK 293 cell line which expresses Renilla luciferase reporter gene under the transcriptional control of the smad binding element (SBE). SMADs are intracellular signaling mediators that transduce extracellular signals from transforming growth factor beta (TGF-beta) ligands to the nucleus where they activate downstream gene transcription. The TGF-beta signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo including cell growth, cell differentiation, apoptosis, cellular homeostasis and other cellular functions. The SBE induction by TGF-beta is shown in Figure 1. |
SK-OV-3 Luciferase Reporter Cell Line |
|
ABC-RC149H |
AcceGen |
each |
Ask for price |
|
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NFAT Luciferase Reporter-HEK293 Cell Line |
|
RC1010 |
BosterBio |
1 Vial, Each vial contains 2 ~ 3 x 10^6 cells in 1 ml of 90% FBS + 10% DMSO. |
EUR 1864.8 |
|
Description: The NFAT Luciferase Reporter cell line is a stably transfected HEK 293 cell line which expresses Renilla luciferase reporter gene under the transcriptional control of the Nuclear Factor of Activated T-cells (NFAT) response element, so that the cell line is designed to measure the transcriptional activity of NFAT. NFAT is a transcription factor originally found in activated T lymphocytes, and is now known to regulate not only T cell activation and differentiation but also the function of other immune cells including dendritic cells, B cells and megakaryocytes. The NFAT induction by calcium ionophore A23187 is shown in Figure 1. |
NFAT Luciferase Reporter-RAW264.7 Cell Line |
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RC1011 |
BosterBio |
1 Vial, Each vial contains 2 ~ 3 x 10^6 cells in 1 ml of 90% FBS + 10% DMSO. |
EUR 1864.8 |
Description: The NFAT Luciferase Reporter cell line is a stably transfected RAW264.7 cell line which expresses Renilla luciferase reporter gene under the transcriptional control of the Nuclear Factor of Activated T-cells (NFAT) response element, so that the cell line is designed to measure the transcriptional activity of NFAT. NFAT is a transcription factor originally found in activated T lymphocytes, and is now known to regulate not only T cell activation and differentiation but also the function of other immune cells including dendritic cells, B cells and megakaryocytes. The NFAT induction by calcium ionophore A23187 is shown in Figure 1. |
iNOS Luciferase Reporter-RAW264.7 Cell Line |
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RC1015 |
BosterBio |
1 Vial, Each vial contains 2 ~ 3 x 10^6 cells in 1 ml of 90% FBS + 10% DMSO. |
EUR 1864.8 |
|
Description: The iNOS Luciferase Reporter cell line is a stably transfected RAW264.7 cell line which expresses Renilla luciferase reporter gene under the transcriptional control of the iNOS promoter. Inducible nitric oxide synthase (iNOS) is an inducible enzyme that catalyzes the production of nitric oxide (NO) from L-arginine. NO is one of the smallest signaling molecules that can diffuse into the cell and is involved in various physiological functions, pathogenesis of septic shock, many diseases associated with autoimmunity, and tumorigenesis. iNOS gene is generally known to be induced by various proinflammatory cytokines and pathogen-associated molecular patterns such as Toll-like receptor (TLR) ligands. The iNOS induction by lipopolysaccharide (LPS), the TLR4 ligand, is shown in Figure 1. |
ISRE Luciferase Reporter-RAW264.7 Cell Line |
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RC1041 |
BosterBio |
1 Vial, Each vial contains 2 ~ 3 x 10^6 cells in 1 ml of 90% FBS + 10% DMSO. |
EUR 1864.8 |
Description: The ISRE Luciferase Reporter cell line is a stably transfected RAW264.7 cell line which expresses Renilla luciferase reporter gene under the transcriptional control of the Interferon-Stimulated Response Element (ISRE), so that the cell line is designed to monitor the JAK/STAT signaling pathway activity. This cell line can be activated by type I IFNs as well as certain Toll like receptor ligands capable of induction of IRFs such as TLR3 ligand-poly (I:C). Functional activity of the cell line has been validated by poly (I:C) (Figure 1). |
ISRE Luciferase Reporter-HEK293 Cell Line |
|
RC1043 |
BosterBio |
1 Vial, Each vial contains 2 ~ 3 x 10^6 cells in 1 ml of 90% FBS + 10% DMSO. |
EUR 1864.8 |
Description: The ISRE Luciferase Reporter cell line is a stably transfected HEK293 cell line which expresses Renilla luciferase reporter gene under the transcriptional control of the Interferon-Stimulated Response Element (ISRE), so that the cell line is designed to monitor the JAK/STAT signaling pathway activity. Functional activity of the cell line has been validated by IFN-alpha (Figure 1). |
GATA3 Luciferase Reporter-HEK293 Cell Line |
|
RC1009 |
BosterBio |
1 Vial, Each vial contains 2 ~ 3 x 10^6 cells in 1 ml of 90% FBS + 10% DMSO. |
EUR 1864.8 |
|
Description: The GATA3 Luciferase Reporter cell line is a stably transfected HEK 293 cell line which expresses Renilla luciferase reporter gene under the transcriptional control of the GATA3 response element, so that the cell line is designed to measure the transcriptional activity of GATA3. As a zinc-finger transcription factor, GATA3 (GATA-binding protein 3) plays a critical role in early and late T cell differentiation, which regulates Th1/Th2 differentiation. GATA3 has been shown to induce Th2 differentiation and repress Th1 differentiation. GATA3 is also known to promote the secretion of IL-4, IL-5 and IL-13 from Th2 cells. The GATA3 induction by phorbol 12-myristate 13-acetate (PMA) is shown in Figure 1. |
STAT1 Luciferase Reporter-RAW264.7 Cell Line |
|
RC1013 |
BosterBio |
1 Vial, Each vial contains 2 ~ 3 x 10^6 cells in 1 ml of 90% FBS + 10% DMSO. |
EUR 4536 |
|
Description: The STAT1 Luciferase Reporter cell line is a stably transfected RAW264.7 cell line which expresses Renilla luciferase reporter gene under the transcriptional control of the interferon (IFN) gamma activation sequence-based STAT1 response element, so that the cell line is designed to measure the transcriptional activity of STAT1. As a transcription factor, Signal Transducer and Activator of Transcription 1 (STAT1) is activated through phosphorylation at tyrosine 701 in response to various cytokines and growth factors such as IFN-alpha, IFN-gamma, IL-6, EGF and PDGF. The phosphorylated STAT1 forms homodimers or heterodimers with STAT3, and the dimers translocate to nucleus in which DNA binding/promoter induction occurs. The STAT1 induction by IFN-gamma is shown in Figure 1. |
STAT3 Luciferase Reporter-HEK293 Cell Line |
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RC1014 |
BosterBio |
1 Vial, Each vial contains 2 ~ 3 x 10^6 cells in 1 ml of 90% FBS + 10% DMSO. |
EUR 4536 |
|
Description: The STAT3 Luciferase Reporter cell line is a stably transfected HEK 293 cell line which expresses Renilla luciferase reporter under the transcriptional control of the STAT3 responsive promoter, so that the cell line is designed to measure the transcriptional activity of STAT3. As a transcription factor, Signal Transducer and Activator of Transcription 3 (STAT3) is activated through phosphorylation at tyrosine 705 in response to various cytokines including IL-6, interferons, epidermal growth factor, hepatocyte growth factor and leukemia inhibitory factor. The phosphorylated STAT3 forms homodimers or heterodimers with STAT1, and the dimers translocate to nucleus in which DNA binding/promoter induction occurs. The STAT3 induction by IL-6 is shown in Figure 1. |
STAT4 Luciferase Reporter-HEK293 Cell Line |
|
RC1040 |
BosterBio |
1 Vial, Each vial contains 2 ~ 3 x 10^6 cells in 1 ml of 90% FBS + 10% DMSO. |
EUR 4536 |
|
Description: The STAT4 Luciferase Reporter cell line is a stably transfected HEK 293 cell line which expresses Renilla luciferase reporter gene under the transcriptional control of the STAT4 responsive promoter, so that the cell line is designed to measure the transcriptional activity of STAT4. Signal Transducer and Activator of Transcription 4 (STAT4) is a member of the STAT transcription factor family and plays a central role in generating inflammation during protective immune responses and immune-mediated diseases. The STAT4 induction by interferon gamma is shown in Figure 1. |
FOXP3 Luciferase Reporter-Jurkat Cell Line |
|
RC1044 |
BosterBio |
1 Vial, Each vial contains 2 ~ 3 x 10^6 cells in 1 ml of 90% FBS + 10% DMSO. |
EUR 1864.8 |
|
Description: The FOXP3 Luciferase Reporter cell line is a stably transfected Jurkat T cell line which expresses Renilla luciferase reporter gene under the transcriptional control of the Forkhead box P3 (FOXP3) promoter. As a member of the forkhead transcription factor family, FOXP3 is a key transcription factor that functions in the development and function of regulatory T cells. Functional activity of the cell line has been validated by phorbol 12-myristate 13-acetate (PMA) in the presence of ionomycin (Figure 1). |
Human p53 Luciferase Reporter Cell Line- RKO |
|
ABC-RC0038 |
AcceGen |
1 vial |
Ask for price |
|
Description: Human p53 Luciferase Reporter Cell Line- RKO is derived from human colon cancer, and stably express firefly luciferase reporter gene under the control of the p53 response element. This cell line is an ideal cellular model for monitoring the activation of p53 Pathway triggered by stimuli treatment,enforced gene expression and gene knockdown. |
STAT5 Luciferase Reporter-Ba/F3 Cell Line |
|
RC1035 |
BosterBio |
1 Vial, Each vial contains 2 ~ 3 x 10^6 cells in 1 ml of 90% FBS + 10% DMSO. |
EUR 4536 |
|
Description: The STAT5 Luciferase Reporter cell line is a stably transfected Ba/F3 cell line which expresses Renilla luciferase reporter gene under the transcriptional control of the STAT5 responsive promoter, so that the cell line is designed to measure the transcriptional activity of STAT5. As a transcription factor, Signal Transducer and Activator of Transcription 5 (STAT5) is activated through phosphorylation at tyrosine 694 in response to many cytokines and growth factors including IL-2, IL-3, GM-CSF and prolactin. Aberrant STAT5 activity is closely related to a wide range of human cancers as STAT5 is often found to be constitutively phosphorylated in cancer cells. The phosphorylated STAT5 forms homodimers or heterodimers with other STATs, and the dimers translocate to nucleus in which DNA binding/promoter induction occurs. The STAT5 induction by IL-3 is shown in Figure 1. |
STAT4 Luciferase Reporter-Ba/F3 Cell Line |
|
RC1045 |
BosterBio |
1 Vial, Each vial contains 2 ~ 3 x 10^6 cells in 1 ml of 90% FBS + 10% DMSO. |
EUR 4536 |
|
Description: The STAT4 Luciferase Reporter cell line is a stably transfected Ba/F3 cell line which expresses Renilla luciferase reporter gene under the transcriptional control of the STAT4 responsive promoter, so that the cell line is designed to measure the transcriptional activity of STAT4. Signal Transducer and Activator of Transcription 4 (STAT4) is a member of the STAT transcription factor family and plays a central role in generating inflammation during protective immune responses and immune-mediated diseases. The STAT4 induction by interferon gamma is shown in Figure 1. |
Human p53 Luciferase Reporter Cell Line- HeLa |
|
ABC-RC0037 |
AcceGen |
1 vial |
Ask for price |
|
Description: Human p53 Luciferase Reporter Cell Line- HeLa is derived from human cervical cancer, and stably express firefly luciferase reporter gene under the control of the p53 response element. This cell line is an ideal cellular model for monitoring the activation of p53 Receptor Signaling Pathway triggered by stimuli treatment, enforced gene expression and gene knockdown. |
Human GR Luciferase Reporter Cell Line-HeLa |
|
ABC-RC0014 |
AcceGen |
1 vial |
Ask for price |
|
Description: Human GR Luciferase Reporter Cell Line-HeLa is derived from human cervical cancer, and stably express firefly luciferase reporter gene under the control of GR response element. This cell line is an ideal cellular model for monitoring the activation of Glucocorticoid Signaling Receptor Signaling Pathway triggered by stimuli treatment, enforced gene expression and gene knockdown. |
Human IRF Luciferase Reporter Cell Line- HepG2 |
|
ABC-RC0021 |
AcceGen |
1 vial |
Ask for price |
|
Description: Human IRF Luciferase Reporter Cell Line- HepG2 is derived from Human Liver Cancer, and stably express firefly luciferase reporter gene under the control of IRF response element. This cell line is an ideal cellular model for monitoring the activation of Immune Response Pathway triggered by stimuli treatment, enforced gene expression and gene knockdown. |
Human NFAT Luciferase Reporter Cell Line- HeLa |
|
ABC-RC0023 |
AcceGen |
1 vial |
Ask for price |
|
Description: Human NFAT Luciferase Reporter Cell Line- HeLa is derived from human cervical cancer, and stably express firefly luciferase reporter gene under the control of NFAT response element. This cell line is an ideal cellular model for monitoring the activation of Calcium Signaling Receptor Signaling Pathway triggered by stimuli treatment, enforced gene expression and gene knockdown. |
IL-8 Luciferase Reporter-RAW264.7 Cell Line |
|
RC1001 |
BosterBio |
1 Vial, Each vial contains 2 ~ 3 x 10^6 cells in 1 ml of 90% FBS + 10% DMSO. |
EUR 1864.8 |
Description: The IL-8 Luciferase Reporter cell line is a stably transfected RAW 264.7 cell line which expresses Renilla luciferase reporter gene under the transcriptional control of the IL-8 promoter. IL-8 is one of the key proinflammatory chemokines or cytokines, which is produced by macrophages and other epithelial cells. Induction of IL-8 is associated with inflammation. The IL-8 induction by Toll-like receptor 4 (TLR4) ligand, LPS, is shown in Figure 1. |
AP-1 Luciferase Reporter-HEK293 Cell Line |
|
RC1002 |
BosterBio |
1 Vial, Each vial contains 2 ~ 3 x 10^6 cells in 1 ml of 90% FBS + 10% DMSO. |
EUR 1864.8 |
|
Description: The AP-1 Luciferase Reporter cell line is a stably transfected HEK 293 cell line which expresses Renilla luciferase reporter gene under the transcriptional control of the activator protein 1 (AP-1). The AP-1 transcription factors are homo- or hetero-dimers that consist of proteins belonging to a group of structurally and functionally related members of the Jun family (c-Jun, JunB and JunD), the Fos (c-Fos, FosB, Fra-1 and Fra-2) and the subfamilies of ATF (ATFa, ATF-2 and ATF-3) and JDP (JDP-1 and JDP-2). The AP-1 induction by phorbol 12-myristate 13-acetate (PMA) is shown in Figure 1. |
Human HIF Luciferase Reporter Cell Line-Hela |
|
ABC-RC0016 |
AcceGen |
1 vial |
Ask for price |
|
Description: Human HIF Luciferase Reporter Cell Line-Hela is derived from human cervical cancer, and stably express firefly luciferase reporter gene under the control of HIF response element. This cell line is an ideal cellular model for monitoring the activation of Hypoxia Response Signaling Receptor Signaling Pathway triggered by stimuli treatment, enforced gene expression and gene knockdown. |
Human IRF Luciferase Reporter Cell Line- HEK293 |
|
ABC-RC0020 |
AcceGen |
1 vial |
Ask for price |
|
Description: Human IRF Luciferase Reporter Cell Line- HEK293 is derived from human embryonic kidney, and stably express firefly luciferase reporter gene under the control of IRF response element. This cell line is an ideal cellular model for monitoring the activation of Immune Response Pathway triggered by stimuli treatment, enforced gene expression and gene knockdown. |
Human Stat1 Luciferase Reporter Cell Line- Hela |
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ABC-RC0040 |
AcceGen |
1 vial |
Ask for price |
|
Description: Human Stat1 Luciferase Reporter Cell Line- Hela is derived from human cervical cancer,and stably express firefly luciferase reporter gene under the control of the STAT1 response element. This cell line is an ideal cellular model for monitoring the activation of JAK-STAT Receptor Signaling Pathway triggered by stimuli treatment, enforced gene expression and gene knockdown. |
Human Stat3 Luciferase Reporter Cell Line- Hela |
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ABC-RC0041 |
AcceGen |
1 vial |
Ask for price |
|
Description: Human Stat3 Luciferase Reporter Cell Line- Hela is derived from human cervical cancer, and stably express firefly luciferase reporter gene under the control of the STAT3 response element. This cell line is an ideal cellular model for monitoring the activation of JAK-STAT Receptor Signaling Pathway triggered by stimuli treatment, enforced gene expression and gene knockdown. |
Mouse NFkB Luciferase Reporter Cell Line-MEF |
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ABC-RC0067 |
AcceGen |
1 vial |
Ask for price |
|
Description: Mouse NFkB Luciferase Reporter Cell Line-MEF is derived from murine embryonic fibroblast,and stably express firefly luciferase reporter gene under the control of NFkB response element. This cell line is an ideal cellular model for monitoring the activation of NFkB Signaling Pathway triggered by stimuli treatment, enforced gene expression and gene knockdown. |
NF-kB Luciferase Reporter-RAW264.7 Cell Line |
|
RC1000 |
BosterBio |
1 Vial, Each vial contains 2 ~ 3 x 10^6 cells in 1 ml of 90% FBS + 10% DMSO. |
EUR 1864.8 |
|
Description: The NF-kB Luciferase Reporter cell line is a stably transfected RAW 264.7 cell line which expresses Renilla luciferase reporter gene under the transcriptional control of the NF-kB response element. NF-kB is a key transcription factor that is involved in immune and inflammatory responses, developmental processes, cellular growth and apoptosis. |
MIP-2 Luciferase Reporter-HEK293 Cell Line |
|
RC1003 |
BosterBio |
1 Vial, Each vial contains 2 ~ 3 x 10^6 cells in 1 ml of 90% FBS + 10% DMSO. |
EUR 1864.8 |
|
Description: The MIP-2 Luciferase Reporter cell line is a stably transfected HEK 293 cell line which expresses Renilla luciferase reporter gene under the transcriptional control of the MIP-2 promoter. Macrophage inflammatory protein 2 (MIP-2) is a small cytokine that belongs to the C-X-C chemokine family and is also known as CXCL2. MIP-2 is one of the major proinflammatory cytokines, which is induced by innate immune receptors such TLRs and Nods, and also mediates LPS-induced osteoclastogenesis. The MIP-2 induction by phorbol 12-myristate 13-acetate (PMA) is shown in Figures 1. |
MIP-2 Luciferase Reporter-RAW264.7 Cell Line |
|
RC1004 |
BosterBio |
1 Vial, Each vial contains 2 ~ 3 x 10^6 cells in 1 ml of 90% FBS + 10% DMSO. |
EUR 1864.8 |
|
Description: The MIP-2 Luciferase Reporter cell line is a stably transfected RAW264.7 cell line which expresses Renilla luciferase reporter gene under the transcriptional control of the MIP-2 promoter. Macrophage inflammatory protein 2 (MIP-2) is a small cytokine that belongs to the C-X-C chemokine family and is also known as CXCL2. MIP-2 is one of the major proinflammatory cytokines, which is induced by innate immune receptors such TLRs and Nods, and also mediates LPS-induced osteoclastogenesis. The MIP-2 induction by Toll-like receptor 4 (TLR4) ligand, LPS, is shown in Figure 1. |
Transgenic crops have been additionally remodeled with genes from numerous species for drought tolerance. The UK (principally with transgenesis and site-specific nucleases) and France (with no transgenic instruments however with MAS and site-specific nucleases) are the primary nations finishing up analysis applications for each biotic stress and drought tolerance. Thus, few European nations used transgenesis for gluten protein composition and RNAi-mediated silencing in celiac illness. Because of vandalism discipline trials of transgenics dropped since 2000. No transgenic wheat is cultivated in Europe for political causes.