The challenges and future of oral drug delivery: An interview with David Brayden.

David Brayden speaks to Hannah Makin, Commissioning Editor: David Brayden is a Full Professor (Advanced Drug Delivery) at the School of Veterinary Medicine, University College Dublin (UCD) and also a Fellow of the UCD Conway Institute.

Following a PhD in Pharmacology at the University of Cambridge, UK (1989), and a postdoctoral research fellowship at Stanford University, CA, USA, he set up Elan Biotechnology Research’s in vitro pharmacology laboratory in Dublin (1991).

At Elan, he became a senior scientist and project manager of several of Elan’s joint-venture drug delivery research collaborations with US biotech companies. In 2001, he joined UCD as a lecturer in veterinary pharmacology and was appointed Associate Professor in 2006 and Full Professor in 2014.

He was a Director of the Science Foundation Ireland Research Cluster (The Irish Drug Delivery ResearchNetwork) from 2007 to 2013, is a Deputy Coordinator of an FP7 Consortium on oral peptides in nanoparticles (‘TRANS-INT’, 2012-2017), and is a Co-Principal Investigator in ‘CURAM’, Science Foundation Ireland’s new Centre for Medical Devices (2014-2020 [ 1 ]).

He was made a Fellow of the Controlled Release Society in 2012. He is the author or co-author of>>200 research publications and patents.

D Brayden serves on the Editorial Advisory Boards of Drug Discovery Today, European Journal of Pharmaceutical Sciences, Advanced Drug Delivery Reviews and the Journal of Veterinary Pharmacology and Therapeutics, and is an Associate Editor of Therapeutic Delivery.

AKR/12B-2
ABC-TC205S 1 vial Ask for price
Description: Tissue: thymus; Transformed by: X-rays. The cells express Lyt-2, Lyt-3 and CD4 in the cytosol, but not on the membrane; They reexpress Lyt-2, Lyt-3 and CD4 on the membrane after sorting by magnetic particles (5 cycles).

AKR/12B-3
ABC-TC206S 1 vial Ask for price
Description: Tissue: thymus; Transformed by: X-rays. The cells express Lyt-2, Lyt-3 and CD4 in the cytosol, but not on the membrane; They do not reexpress Lyt-2, Lyt-3 and CD4 on the membrane after sorting by magnetic particles (5 cycles).

Ala-Lys-Arg (AKR)
070-06 5 mg
EUR 102.6

Recombinant Chicken Homeobox protein AKR
MBS1464784-002mgBaculovirus 0.02mg(Baculovirus)
EUR 1150

Recombinant Chicken Homeobox protein AKR
MBS1464784-002mgEColi 0.02mg(E-Coli)
EUR 785

Recombinant Chicken Homeobox protein AKR
MBS1464784-002mgYeast 0.02mg(Yeast)
EUR 940

Recombinant Chicken Homeobox protein AKR
MBS1464784-01mgEColi 0.1mg(E-Coli)
EUR 940

Recombinant Chicken Homeobox protein AKR
MBS1464784-01mgYeast 0.1mg(Yeast)
EUR 1100

Recombinant Neurospora crassa Palmitoyltransferase AKR1 (akr-1)
MBS7007634-002mg 0.02mg
EUR 2125

Recombinant Neurospora crassa Palmitoyltransferase AKR1 (akr-1)
MBS7007634-01mg 0.1mg
EUR 3050

Recombinant Neurospora crassa Palmitoyltransferase AKR1 (akr-1)
MBS7007634-5x01mg 5x0.1mg
EUR 13680

Recombinant Neurospora crassa Palmitoyltransferase AKR1 (akr-1), partial
MBS7087629-INQUIRE INQUIRE Ask for price

LYS-006
555854 50.0mg
EUR 1250

CCI-006
462390 5.0mg
EUR 530

GBO-006
MBS131756-100mg 100mg
EUR 1065

GBO-006
MBS131756-500mg 500mg
EUR 2925

CCI-006
HY-114410 10 mg
EUR 1515.18
Description: CCI-006 is a selective inhibitor and chemosensitizer of MLL-rearranged leukemia cells, by inhibits mitochondrial respiration resulting in insurmountable mitochondrial depolarization and a pro-apoptotic unfolded protein response (UPR) in a subset of MLL-r leukemia cells[1].

OKI-006
HY-144893 Get quote Ask for price
Description: OKI-006 is a potent and orally active inhibitor of histone deacetylase (HDAC). OKI-006 is a unique congener of the natural product HDAC inhibitor largazole. Histone deacetylases (HDACs) play critical roles in epigenomic regulation, and histone acetylation is dysregulated in many human cancers. OKI-006 has the potential for the research of cancer disease[1].

ZL-006
MBS3600618-10mg 10mg
EUR 250

ZL-006
MBS3600618-25mg 25mg
EUR 330

ZL-006
MBS3600618-50mg 50mg
EUR 435

ZL-006
MBS3600618-5x50mg 5x50mg
EUR 1640

CCI-006
MBS3843051-10mg 10mg
EUR 810

CCI-006
MBS3843051-50mg 50mg
EUR 2370

CCI-006
MBS3843051-5mg 5mg
EUR 465

CCI-006
MBS3843051-5x50mg 5x50mg
EUR 10655

CCI-006
MBS5752876-100mg 100mg
EUR 1715

CCI-006
MBS5752876-10mg 10mg
EUR 445

CCI-006
MBS5752876-1mg 1mg
EUR 210

CCI-006
MBS5752876-50mg 50mg
EUR 1165

CCI-006
MBS5752876-5mg 5mg
EUR 310

SDB-006
S210005 100mg
EUR 3000
Description: 695213-59-3

CCI-006
T10706-10mg 10mg Ask for price
Description: CCI-006

CCI-006
T10706-1g 1g Ask for price
Description: CCI-006

CCI-006
T10706-1mg 1mg Ask for price
Description: CCI-006

CCI-006
T10706-50mg 50mg Ask for price
Description: CCI-006

CCI-006
T10706-5mg 5mg Ask for price
Description: CCI-006

SDB-006
TRC-S210005-100MG 100 mg Ask for price

HTH-02-006
HY-156397 Get quote Ask for price
Description: HTH-02-006 is a NUAK2 inhibitor (IC50?=?126?nM). HTH-02-006 reduces levels of phosphorylated MYPT1 in HuCCT-1 cells. HTH-02-006 inhibits YAP-driven cell proliferation, hepatomegaly and tumorigenesis. HTH-02-006 also has antifibrotic protective effect[1][2].

NSC 207895 (XI-006)
A4209-10 10 mg
EUR 240
Description: Apoptosis|MDM2

NSC 207895 (XI-006)
A4209-25 25mg
EUR 320
Description: Apoptosis|MDM2

NSC 207895 (XI-006)
A4209-5 5 mg
EUR 136
Description: Apoptosis|MDM2

NSC 207895 (XI-006)
A4209-50 50 mg
EUR 1053
Description: MDMX inhibitor,anti-cancer agent

NSC-207895 (XI-006)
MBS385828-100mg 100mg
EUR 1440

NSC-207895 (XI-006)
MBS385828-10mg 10mg
EUR 245

NSC-207895 (XI-006)
MBS385828-50mg 50mg
EUR 870

NSC-207895 (XI-006)
MBS385828-5mg 5mg
EUR 180

NSC-207895 (XI-006)
MBS385828-5x100mg 5x100mg
EUR 6480

Mouse Esophageal Cancer Cell Line-AKR
CC7F9 1x 10^6 Cells/Vial Ask for price

Recombinant ASFV War-006 Protein
VAng-0978Lsx-inquire inquire Ask for price
Description: African swine fever virus (isolate Warthog/Namibia/Wart80/1980) Protein MGF 110-1L (War-006), partial, recombinant protein from E. coli. (Uniprot ID: P0C9G1)

Temiz DVB-Sty MP-006
10-01-0100-002 100 g Ask for price

Temiz DVB-SAX MP-006
10-10-0100-002 100 g Ask for price

Rabbit anti-AKV murine leukemia virus (AKR (endogenous) murine leukemia virus) POL Polyclonal Antibody
MBS7161921-INQUIRE INQUIRE Ask for price

Rabbit anti-AKV murine leukemia virus (AKR (endogenous) murine leukemia virus) env Polyclonal Antibody
MBS7161930-INQUIRE INQUIRE Ask for price

Rabbit anti-AKV murine leukemia virus (AKR (endogenous) murine leukemia virus) GAG Polyclonal Antibody
MBS7166574-INQUIRE INQUIRE Ask for price

Mouse Esophageal Cancer Cell Line-AKR-GFP-Puro
CC9F71 1x 10^6 Cells/Vial Ask for price

Anti-CD74 (006 (A))-VC-MMAE ADC
ADC-W-037 1mg Ask for price
Description: This ADC product is comprised of an anti-CD74 monoclonal antibody (006 (A)) conjugated via a VC linker to MMAE

Anti-CD74 (006 (A))-Mc-MMAF ADC
ADC-W-040 1mg Ask for price
Description: This ADC product is comprised of an anti-CD74 monoclonal antibody (006 (A)) conjugated via a Mc linker to MMAF

CRBN (Protein Cereblon, AD-006, DKFZp781K0715, MGC27358)
MBS649923-005mg 0.05mg
EUR 630

CRBN (Protein Cereblon, AD-006, DKFZp781K0715, MGC27358)
MBS649923-5x005mg 5x0.05mg
EUR 2680

CD10 Recombinant Rabbit mAb (SDT-006-77)
S0B2260 100 μL
EUR 45

Kinesis Inline MicrFiltr Bdy .006 thru - EACH
CHR3639 EACH
EUR 62.1

Lenti ORF particles, AKR1C3 (Myc-DDK tagged) - Human aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II) (AKR
RC200210L1V 200 µl Ask for price

Lenti ORF particles, AKR1C3 (Myc-DDK tagged) - Human aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II) (AKR
RC200210L3V 200 µl Ask for price

Keratin 18 Monoclonal antibody [Clone: EBS-IF-006]
EBS-IF-006-100ug 100 ug
EUR 141.79
Description: Demonstration of keratin 18 in immunohistochemistry, immunofluorescence tests and immunoblotting.

Keratin 18 Monoclonal antibody [Clone: EBS-IF-006]
EBS-IF-006-1mg 1 mg
EUR 897.6
Description: Demonstration of keratin 18 in immunohistochemistry, immunofluorescence tests and immunoblotting.

Keratin 18 Monoclonal antibody [Clone: EBS-IF-006]
EBS-IF-006-500ug 500 ug
EUR 479.6
Description: Demonstration of keratin 18 in immunohistochemistry, immunofluorescence tests and immunoblotting.

MADER (NAB2) Monoclonal antibody [Clone: EBS-T-006]
EBS-T-006-100ug 100 ug
EUR 141.79
Description: EBS-T-006 can be used on frozen sections. Other applications not known.

MADER (NAB2) Monoclonal antibody [Clone: EBS-T-006]
EBS-T-006-1mg 1 mg
EUR 897.6
Description: EBS-T-006 can be used on frozen sections. Other applications not known.

MADER (NAB2) Monoclonal antibody [Clone: EBS-T-006]
EBS-T-006-500ug 500 ug
EUR 479.6
Description: EBS-T-006 can be used on frozen sections. Other applications not known.

Recombinant ASFV BA71V-006 Protein (aa 1-83)
VAng-0741Lsx-1mg 1 mg
EUR 3490.8
Description: African swine fever virus (strain Badajoz 1971 Vero-adapted) Uncharacterized protein L83L (BA71V-006), recombinant protein from E. coli. (Uniprot ID: Q65132)

Recombinant ASFV BA71V-006 Protein (aa 1-83)
VAng-0741Lsx-500g 500 µg
EUR 2353.2
Description: African swine fever virus (strain Badajoz 1971 Vero-adapted) Uncharacterized protein L83L (BA71V-006), recombinant protein from E. coli. (Uniprot ID: Q65132)

Recombinant ASFV BA71V-006 Protein (aa 1-83)
VAng-0741Lsx-50g 50 µg
EUR 1627.2
Description: African swine fever virus (strain Badajoz 1971 Vero-adapted) Uncharacterized protein L83L (BA71V-006), recombinant protein from E. coli. (Uniprot ID: Q65132)

Recombinant ASFV Ken-006 Protein (aa 1-355)
VAng-0791Lsx-1mg 1 mg
EUR 5685.6
Description: African swine fever virus (isolate Pig/Kenya/KEN-50/1950) Protein MGF 360-3L (Ken-006), recombinant protein from E. coli. (Uniprot ID: P0C9M5)

Recombinant ASFV Ken-006 Protein (aa 1-355)
VAng-0791Lsx-500g 500 µg
EUR 3789.6
Description: African swine fever virus (isolate Pig/Kenya/KEN-50/1950) Protein MGF 360-3L (Ken-006), recombinant protein from E. coli. (Uniprot ID: P0C9M5)

Recombinant ASFV Ken-006 Protein (aa 1-355)
VAng-0791Lsx-50g 50 µg
EUR 2584.8
Description: African swine fever virus (isolate Pig/Kenya/KEN-50/1950) Protein MGF 360-3L (Ken-006), recombinant protein from E. coli. (Uniprot ID: P0C9M5)

Recombinant ASFV Mal-006 Protein (aa 20-116)
VAng-2133Lsx-1mg 1 mg
EUR 3606
Description: African swine fever virus (isolate Tick/Malawi/Lil 20-1/1983) Protein MGF 110-2L (Mal-006), recombinant protein from E. coli. (Uniprot ID: P0C9G7)

Recombinant ASFV Mal-006 Protein (aa 20-116)
VAng-2133Lsx-500g 500 µg
EUR 2419.2
Description: African swine fever virus (isolate Tick/Malawi/Lil 20-1/1983) Protein MGF 110-2L (Mal-006), recombinant protein from E. coli. (Uniprot ID: P0C9G7)

Recombinant ASFV Mal-006 Protein (aa 20-116)
VAng-2133Lsx-50g 50 µg
EUR 1677.6
Description: African swine fever virus (isolate Tick/Malawi/Lil 20-1/1983) Protein MGF 110-2L (Mal-006), recombinant protein from E. coli. (Uniprot ID: P0C9G7)

Recombinant ASFV War-006 Protein (aa 1-269)
VAng-2468Lsx-100g 100 µg
EUR 7731.6
Description: African swine fever virus (isolate Warthog/Namibia/Wart80/1980) Protein MGF 110-1L (War-006), recombinant protein. (Uniprot ID: P0C9G1)

Recombinant ASFV War-006 Protein (aa 1-269)
VAng-2468Lsx-10g 10 µg
EUR 3030
Description: African swine fever virus (isolate Warthog/Namibia/Wart80/1980) Protein MGF 110-1L (War-006), recombinant protein. (Uniprot ID: P0C9G1)

Recombinant ASFV War-006 Protein (aa 1-269)
VAng-2468Lsx-50g 50 µg
EUR 4678.8
Description: African swine fever virus (isolate Warthog/Namibia/Wart80/1980) Protein MGF 110-1L (War-006), recombinant protein. (Uniprot ID: P0C9G1)

CD10 Recombinant Rabbit mAb,PBS Only (SDT-006-77)
S0B2260P 25 μg Ask for price

Recombinant African swine fever virus Uncharacterized protein L83L (BA71V-006)
MBS1454517-002mgBaculovirus 0.02mg(Baculovirus)
EUR 1005

Recombinant African swine fever virus Uncharacterized protein L83L (BA71V-006)
MBS1454517-002mgEColi 0.02mg(E-Coli)
EUR 575

Recombinant African swine fever virus Uncharacterized protein L83L (BA71V-006)
MBS1454517-002mgYeast 0.02mg(Yeast)
EUR 760

Recombinant African swine fever virus Uncharacterized protein L83L (BA71V-006)
MBS1454517-01mgEColi 0.1mg(E-Coli)
EUR 685

Recombinant African swine fever virus Uncharacterized protein L83L (BA71V-006)
MBS1454517-01mgYeast 0.1mg(Yeast)
EUR 890

Recombinant African swine fever virus Protein MGF 110-1L (War-006)
MBS1215569-INQUIRE INQUIRE Ask for price

Recombinant African swine fever virus Protein MGF 110-2L (Mal-006)
MBS1100570-002mgBaculovirus 0.02mg(Baculovirus)
EUR 1020

Recombinant African swine fever virus Protein MGF 110-2L (Mal-006)
MBS1100570-002mgEColi 0.02mg(E-Coli)
EUR 590

Recombinant African swine fever virus Protein MGF 110-2L (Mal-006)
MBS1100570-002mgYeast 0.02mg(Yeast)
EUR 775

Recombinant African swine fever virus Protein MGF 110-2L (Mal-006)
MBS1100570-01mgEColi 0.1mg(E-Coli)
EUR 705

Recombinant African swine fever virus Protein MGF 110-2L (Mal-006)
MBS1100570-01mgYeast 0.1mg(Yeast)
EUR 905

Recombinant African swine fever virus Protein MGF 360-3L (Ken-006)
MBS1036097-002mgBaculovirus 0.02mg(Baculovirus)
EUR 1230

Recombinant African swine fever virus Protein MGF 360-3L (Ken-006)
MBS1036097-002mgEColi 0.02mg(E-Coli)
EUR 890

Recombinant African swine fever virus Protein MGF 360-3L (Ken-006)
MBS1036097-002mgYeast 0.02mg(Yeast)
EUR 1020

Recombinant African swine fever virus Protein MGF 360-3L (Ken-006)
MBS1036097-01mgEColi 0.1mg(E-Coli)
EUR 1070

Recombinant African swine fever virus Protein MGF 360-3L (Ken-006)
MBS1036097-01mgYeast 0.1mg(Yeast)
EUR 1160

Recombinant African swine fever virus Protein MGF 110-1L (War-006)
MBS7036023-002mg 0.02mg
EUR 1570

D Brayden works as an independent consultant for drug delivery companies.